On the Untraceability of Anonymous RFID Authentication Protocol with Constant Key-Lookup

A*Star SER

Toward Robust Hidden Volumes Using Write-Only Oblivious RAM

With sensitive data being increasingly stored on mobile devices and laptops, hard disk encryption is more important than ever. In particular, being able to plausibly deny that a hard disk contains certain information is a very useful and interesting research goal. However, it has been known for some time that existing “hidden volume ” solutions, like TrueCrypt, fail in the face of an adversary who is able to observe the contents of a disk on multiple, separate occasions. In this work, we explore more robust constructions for hidden volumes and present HIVE, which is resistant to more powerful adversaries with multiple-snapshot capabilities. In pursuit of this, we propose the first security definitions for hidden volumes, and prove HIVE secure under these definitions. At the core of HIVE, we design a new write-only Oblivious RAM. We show that, when only hiding writes, it is possible to achieve ORAM with optimal O(1) communication complexity and only poly-logarithmic user memory. This is a significant improvement over existing work and an independently interesting result. We go on to show that our writeonly ORAM is specially equipped to provide hidden volume functionality with low overhead and significantly increased security. Finally, we implement HIVE as a Linux kernel block device to show both its practicality and usefulness on existing platforms. 1

Identification and Mitigation of Reactive Metabolites of 2‑Aminoimidazole-Containing Microsomal Prostaglandin E Synthase‑1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury

Two 2-aminoimidazole-based inhibitors, LY3031207 (<b>1</b>) and LY3023703 (<b>2</b>), of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme were found to cause drug-induced liver injury (DILI) in humans. We studied imidazole ring substitutions to successfully mitigate reactive metabolite (RM) formation. These studies support the conclusion that RM formation may play a role in the observations of DILI and the consideration of 2-aminoimidazoles as structure alerts, due to the high likelihood of bioactivation to generate RMs

Identification and Mitigation of Reactive Metabolites of 2‑Aminoimidazole-Containing Microsomal Prostaglandin E Synthase‑1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury

Two 2-aminoimidazole-based inhibitors, LY3031207 (<b>1</b>) and LY3023703 (<b>2</b>), of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme were found to cause drug-induced liver injury (DILI) in humans. We studied imidazole ring substitutions to successfully mitigate reactive metabolite (RM) formation. These studies support the conclusion that RM formation may play a role in the observations of DILI and the consideration of 2-aminoimidazoles as structure alerts, due to the high likelihood of bioactivation to generate RMs

Catalytic Transfer Deuteration and Hydrodeuteration: Emerging Techniques to Selectively Transform Alkenes and Alkynes to Deuterated Alkanes

Increasing demand for deuterium-labeled organic molecules has spurred a renewed interest in selective methods for deuterium installation. Catalytic transfer deuteration and transfer hydrodeuteration are emerging as powerful techniques for the selective incorporation of deuterium into small molecules. These reactions not only obviate the use of D2 gas and pressurized reaction setups but provide new opportunities for selectively installing deuterium into small molecules. Commercial or readily synthesized deuterium donors are typically employed as easy-to-handle reagents for transfer deuteration and hydrodeuteration reactions. In this minireview, recent advances in the catalytic transfer deuteration and hydrodeuteration of alkenes and alkynes for the selective synthesis of deuterated alkanes will be discussed